A SUBSET OF CB002 XANTHINE ANALOGS BYPASS P53-SIGNALING TO RESTORE A P53 TRANSCRIPTOME AND TARGET AN S-PHASE CELL CYCLE CHECKPOINT IN TUMORS WITH MUTATED-P53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance.CB002 and structural-analogs Bottoms restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregulate t

This research aims at : -Recognizing the ratio of contribution belonging to the bodily measurements and the elements of fitness and its relation with the variable of Anaerobic capacity.-Building an equation of predicting the Anaerobic capacity through the bodily measurements and the elements of bodily measurements.In the light of theses aims the re

Recent Indian rule on compensation for any injury or death of the subject in a clinical trial, has generated a lot of Sox ballast discussion on its impact on clinical trials in India.The legal process in the compensation rule is based on the causality assessment.However, it ignores the scientific basis of causality assessment.This could have far re

The article traces the history of Omsk State Technical University on the basis of archival documents.The ancestor of Omsk machine-building institute (further Omsk Polytechnical Institute, Omsk State Technical University) was Voroshilovgrad (Lugansk) kids purse evening machine-building institute, which was relocated from Ukraine to Omsk at the begin